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Abu al-Qasim was born in the city of El Zahra, six miles northwest of Córdoba, Spain. He was descended from the Ansar Arab tribe who settled earlier in Spain. Few details remain regarding his life, aside from his published work, due to the destruction of El-Zahra during later Spanish-Moorish conflicts. His name first appears in the writings of Abu Muhammad bin Hazm (993 - 1064), who listed him among the greatest physicians of Moorish Spain. But we have the first detailed biography of El-Zahrawi from al-Humaydi's Jadhwat al-Muqtabis (On Andalusian Savants), completed six decades after El-Zahrawi's death.

He lived most of his life in Córdoba. It is also where he studied, taught and practiced medicine and surgery until shortly before his death in about 1013, two years after the sacking of El-Zahra.

The street in Cordoba where he lived is named in his honour as "Calle Albucasis". On this street he lived in house no. 6, which is preserved today by the Spanish Tourist Board with a bronze plaque (awarded in January 1977) which reads "This was the house where lived Abul-Qasim."[2]

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